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王当歌

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简历:

教育背景: 

2009.9-2013.7  复旦大学 药学 学士

2013.8-2018.6  中国科学院上海药物研究所 药剂学 硕博连读

 

工作经历: 

2018.07 - 至今,在中国科学院上海药物研究所从事药物新型制剂的研究工作

2019.01 - 至今,中国科学院上海药物研究所烟台分所,特聘高级工程师

 

工作业绩:

工作期间,致力于新型纳米药物输送系统的设计、构建、药效学评价和作用机理的研究,在基于pH响应性纳米载药系统改善肿瘤治疗效果的研究方面取    得成果。于2019年入选中国科学院青年创新促进会成为第9批会员;入选上海市“科技创新行动计划”青年科技英才扬帆计划;作为学术骨干参与国家重  点基础研究发展计划1项、国家自然科学基金委重点项目1项、面上项目1项。发表SCI论文20篇,其中第一作者或共同第一作者论文6篇,IF>10的3篇,  IF=8-10间的3篇,包括Nat Commun (IF=12.35) 1篇、Nano Lett (IF=12.08) 1篇、ACS Nano (IF=13.71) 1篇、Biomaterials (IF=8.81) 2篇、Small (IF=9.06) 1篇,所发论文累计他引750余次;参与申请中国发明专利1项并获授权1项。

 

承担项目:

1.国家自然科学基金重点项目,81630052,基于红细胞膜的靶向纳米释药系统抗乳腺 癌的肺转移研究,2017.01-2021.12,275万,在研,参加。

2.国家自然科学基金面上项目,31671024,肿瘤微环境自适性纳米载药系统抗乳腺癌 转移及其作用机制研究,2014.01-2017.12,75万,已结题,参加。

3.国家重点基础研究发展计划,2013CB932704,生物医用纳米材料的代谢过程及其分析方法研究,2013.01-2017.08,602万,已结题,参加。

4.上海市“科技创新行动计划”青年科技英才扬帆计划,19YF1457300,阻断PD-1/PD-L1通路的pH响应型纳米粒用于肿瘤免疫治疗的研究,2019.05-2022.04,20万,在研,主持。

 

申请专利:

于海军,李亚平,付元磊,冯兵,周方圆,王当歌,王亭亭.一种三嵌段聚合物、其制备方法及用途  申请号:201510412476.0 

 

发表文章:

5.Dangge Wang#, Tingting Wang#, Jianping Liu, Haijun Yu*, Shi Jiao, Bing Feng, Fangyuan Zhou, Yuanlei Fu, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Zhaocai Zhou, Yaping Li*, Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade Enhanced Cancer Photodynamic Immunotherapy, Nano Lett, 2016, 16(9), 5503-5513.

6.Tingting Wang#, Dangge Wang#, Haijun Yu*, Bing Feng, Fangyuan Zhou, Hanwu Zhang, Lei Zhou, Shi Jiao, Yaping Li*, A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors, Nature Communications, 2018, 9, 1532.

7.Tingting Wang#, Dangge Wang#, Haijun Yu*, Mingwei Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Qi Yin, Zhiwen Zhang, Yongzhuo Huang, Yaping Li*, Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor, Acs Nano, 2016, 10(3), 3496-3508.

8.Dangge Wang, Zhiai Xu, Haijun Yu*, Xianzhi Chen, Bing Feng, Zhirui Cui, Bing Lin, Qi Yin, Zhiwen Zhang, Chunying Chen, Jun Wang, Wen Zhang, Yaping Li*, Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods, Biomaterials, 2014, 35(29), 8374-8384.

9.Dangge Wang#, Tingting Wang#, Zhiai Xu, Haijun Yu*, Bing Feng, Junying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang, Yaping Li*, Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Coloaded with Docetaxel and siRNA, Small, 2016, 12(4), 488-498.

10.Lijun Sun#, Dangge Wang#, Yu Chen*, Liying Wang, Ping Huang, Yaping Li*, Zowei Liu, Heliang Yao, Jianlin Shi*, Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer, Biomaterials, 2017, 133, 219-228.

11.H. Yu, C. Guo, B. Feng, J. Liu, X. Chen, D. Wang, L. Teng, Y. Li, Q. Yin, Z. Zhang, Y. Li, Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer. Theranostics 6, 14-27 (2016).

12.H. J. Yu, Z. A. Xu, D. G. Wang, X. Z. Chen, Z. W. Zhang, Q. Yin, Y. P. Li, Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery. Polym Chem-Uk 4, 5052-5055 (2013).

13.F. Y. Zhou, B. Feng, H. J. Yu, D. G. Wang, T. T. Wang, J. P. Liu, Q. S. Meng, S. L. Wang, P. C. Zhang, Z. W. Zhang, Y. P. Li, Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer. Theranostics 6, 679-687 (2016).

14.B. Feng, Z. Xu, F. Zhou, H. Yu, Q. Sun, D. Wang, Z. Tang, H. Yu, Q. Yin, Z. Zhang, Y. Li, Near infrared light-actuated gold nanorods with cisplatin-polypeptide wrapping for targeted therapy of triple negative breast cancer. Nanoscale 7, 14854-14864 (2015).

15.T. Wang, D. Wang, J. Liu, B. Feng, F. Zhou, H. Zhang, L. Zhou, Q. Yin, Z. Zhang, Z. Cao, H. Yu, Y. Li, Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors. Nano Lett 17, 5429-5436 (2017).

16.B. Feng, F. Y. Zhou, Z. A. Xu, T. T. Wang, D. G. Wang, J. P. Liu, Y. L. Fu, Q. Yin, Z. W. Zhang, H. J. Yu, Y. P. Li, Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy. Advanced Functional Materials 26, 7431-7442 (2016).

17.F. Y. Zhou, B. Feng, T. T. Wang, D. G. Wang, Q. S. Meng, J. F. Zeng, Z. W. Zhang, S. L. Wang, H. J. Yu, Y. P. Li, Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer. Advanced Functional Materials 27,  (2017).

18.F. Y. Zhou, B. Feng, T. T. Wang, D. G. Wang, Z. R. Cui, S. L. Wang, C. Y. Ding, Z. W. Zhang, J. Liu, H. J. Yu, Y. P. Li, Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer. Advanced Functional Materials 27,  (2017).

19.B. Feng, F. Y. Zhou, D. G. Wang, Z. A. Xu, H. J. Yu, Y. P. Li, Gold nanomaterials for treatment of metastatic cancer. Sci China Chem 59, 984-990 (2016).

20.B. Feng, F. Y. Zhou, W. C. Lu, D. G. Wang, T. T. Wang, C. Luo, H. Wang, Y. P. Li, H. J. Yu, Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer. Biomater Sci-Uk 5, 1522-1525 (2017).

21.B. Feng, F. Y. Zhou, B. Hou, D. G. Wang, T. T. Wang, Y. L. Fu, Y. T. Ma, H. J. Yu, Y. P. Li, Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment. Adv Mater 30,  (2018).

22.J. P. Liu, T. T. Wang, D. G. Wang, A. J. Dong, Y. P. Li, H. J. Yu, Smart nanoparticles improve therapy for drug resistant tumors by overcoming pathophysiological barriers. Acta Pharmacol Sin 38, 1-8 (2017).

23.F. Zhou, B. Feng, H. Yu, D. Wang, T. Wang, Y. Ma, S. Wang, Y. Li, Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade. Adv Mater, e1805888 (2019).

24.J. F. Ren, S. Shen, D. G. Wang, Z. J. Xi, L. R. Guo, Z. Q. Pang, Y. Qian, X. Y. Sun, X. G. Jiang, The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2. Biomaterials 33, 3324-3333 (2012).

25.S. Shen, H. Y. Tang, X. T. Zhang, J. F. Ren, Z. Q. Pang, D. G. Wang, H. L. Gao, Y. Qian, X. G. Jiang, W. L. Yang, Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation. Biomaterials 34, 3150-3158 (2013).

 

所获奖励:

1,上海市优秀毕业生,2018.06,上海市教育委员会

2,上海市优秀共青团员,2018.04,共青团上海市委员会

3,博士研究生国家奖学金,2016.12,中华人民共和国教育部


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