欢迎访问烟台药物研究所网站!
站内查询:
科研队伍 您所在的位置:首页 >> 科研队伍 >> 烟台市双百计划人才

张仰明

20190920012248370.png

简历:

中国科学院上海药物研究所研究员,烟台药物研究所特聘研究员

主要从事新药发现研究及候选新药的临床前开发工作,参与及负责了多个创新药物的临床前原料药药学研究和后期的临床申报工作,其中两个新药品种已获得临床批件,并进入临床研究。  

 

研究方向:

1、新药发现研究,基于天然产物关键结构骨架及某些优势结构单元,通过合成方法学研究,开展先导化合物的发现研究;

2、候选新药的临床前开发,以合成工艺研究为切入点,协调推进候选新药的质控、制剂、药效、毒理及药代等项目,在此基础上开展临床申报工作。

 

专家类别:

研究员

 

承担科研项目情况:

1、抗结肠癌候选新药GCJ490-A的临床前开发(CASIMM0120161001),中科院创新研究院,2016.8-2018.7

2、五环三萜类PS1-BACE1相互作用抑制剂的设计合成及其功能研究(81573267),国家自然科学基金面上项目2016.1-2019.12

3、抗癫痫候选新药HN37的临床前开发(16431901700),上海市科技专项重点项目,2016.7-2019.6

4、抗多发性骨髓瘤候选新药必噻司他(倍赛诺他)的临床前研究(14431906100),上海市科技专项重点项目,2014.7-2017.9

 

获奖及荣誉:

2013年赛诺菲—中科院上海生命科学研究院优秀青年人才奖

 

代表论著:

1.        Chaojun Gong, Anhui Gao, Yangming Zhang, Mingbo Su, Fei Chen, Li Sheng,YuBo Zhou, JingYa Li, Jia Li, FaJun Nan. Design, Synthesis and Biological Evaluation of Bisthiazole-based Trifluoromethyl Ketone Derivatives as Potent HDAC Inhibitors with Improved Cellular Efficacy, Eur J Med Chem. 2016, 112, 81-90.

2.        Yang Li, Yajuan Wang, Haijun Chen; Liping Shi, Xiankun Tong,Yangming Zhang, Guifeng Wang, Wenlong Wang, Chunlan Feng, Peilan He, Yibing Xu, Mengji Lu, Wei Tang, Fajun Nan, Jianping Zuo. Effect of a Hepatitis B Virus Hnhibitor, NZ-4, on Capsid Formation, Antivil Res. 2016, 125, 25-33.

3.        *Pingzheng Zhou, *Yangming Zhang, Haiyan Xu, Fei Chen, Xueqin Chen, Xiaoying Li, Xiaoping Pi, Lipeng Wang, Li Zhan, Fajun Nan, and Zhaobing Gao. P-Retigabine: an N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, Mol Pharmacol, 2015, 87, 31,i Ch

4.        Fei Chen, Hui Chai, Mingbo Su, Yangming Zhang, Jia Li, Xin Xie, Fajun Nan. Potent and Orally Efficacious Bisthiazole-based Histone Deacetylase Inhibitors, ACS Med Chem Lett. 2014, 5(6), 628-33.

5.        Li Yang, Liping Shi, Haijun Chen, Xiankun Tong, Guifeng Wang, Yangming Zhang, Wenlong Wang, Chunlan Feng, Peilan He, Fenghua Zhu, Youhua Hao, Baoju Wang, Dongliang Yang, Wei Tang, Fajun Nan, Jianping Zuo. Isothiafludine, a Novel Non-nucleoside Compound, Inhibits Hepatitis B Virus Replication through Blocking Pregenomic RNA Encapsidation, Acta Pharmacol Sin, 2014, 35, 410rmacolMin Gu, Yangming Zhang, Wei Luo, Wei Lu, Fajun Nan. A  Facile Semisythesis of 2¢, 7-Bisacetyltaxol from 10-DAB. Chem. Nat. Compd., 2012, 48, 702-703.

6.        *Mei Zhang, *Yangming Zhang, Wei Lu, Fajun Nan. Synthesis and Revision of Stereochemistry of Rubescensin S, Org Biomol Chem, 2011, 9, 4436-4439.

7.        Xiaoying Li, Yangming Zhang, Jie Tang, Fan Yang, Fajun Nan. One-pot Synthesis of 2,4-Diamino-substituted Thieno[3,2-d]pyrimidines, Chin J Chem, 2010, 28, 1437-1440.

8.        Yangming Zhang, Yu Ding, Wei Tang, Wei Luo, Min Gu, Wei Lu, Jie Tang, Fajun Nan. Synthesis and Biological Evaluation of Immunosuppressive Agent DZ2002 and its Steroisomers, Bioorg Med Chem, 2008, 16, 9212-9216. 

Yangming Zhang, Min Gu, Hui Ma, Jie Tang, Wei Lv, Fajun Nan. An Efficient Synthesis of 2-Chloropyrimidines via Pd-mediated Catalytic Regioselective Dechlorination in the Presence of NaHCO3, Chin J Chem, 2008, 26, 962-964.

10. Qiaojie Xiong, Haiyan Sun, Yangming Zhang, Fajun Nan, Min Li. Combinatorial Augmentation of Voltage-gated KCNQ Potassium Channels by Chemical Openers, Proc Natl Acad Sci USA, 2008, 105, 3128-3133.  


上一个:
下一个:
版权所有 烟台药物研究所 关键词:烟台药物研究所 资质
地址: 山东省烟台市高新区科技大道39号 电话: 86-535-3800269 鲁ICP备13031074号-2