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药物合成实验室

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简历:


教育经历

2013.09-2016.07 沈阳药科大学,药物化学,博士

2009.09-2012.07 锦州医科大学,药物化学,硕士


工作经历:

2016.07—至今 中国科学院上海药物研究所烟台分所


研究方向:

1.抗肿瘤药物的设计与合成,包括基于非小细胞肺癌深厚研究背景的靶点进行新型抗肿瘤药物的设计与合成。

2.抗糖尿病药物的设计与合成,包括长效机制的降糖药物的设计与合成。


发表文章:

1.     Honglei Xie, Yiqun Li, Changlin Bai, Ruifeng Wang, Chunchi Liu, Chenzhou Hao, Bin Lin, Maosheng Cheng, Dongmei Zhao*. Discovery of novel N,N-3-phenyl-3-benzylamin opropionanilides as potent inhibitors of cholesteryl ester transfer protein in vivo. Bioorganic & Medicinal Chemistry, 24 (2016) 1811–1818.

2.     Dongmei Zhao*, Honglei Xie, Changlin Bai, Chunchi Liu, Chenzhou Hao, Shizhen Zhao, Hongli Yuan, Changqun Luo, Jian Wang, Bin Lin, Jiang Zheng, Maosheng Cheng. Design, synthesis and biological evaluation of N,N-3-phenyl-3-benzylaminopro panamide derivatives as novel Cholesteryl Ester Transfer Protein inhibitor. Bioorganic & Medicinal Chemistry, 24 (2016) 1589–1597.

3.     Honglei Xie, Yuyang Liu, Ying Peng*, Dongmei Zhao*, Jiang Zheng*. Detection of protein adduction derived from dauricine by alkaline permethylation. Analytical and Bioanalytical Chemistry, 408 (2016) 4111-4119.

4.     Honglei Xie, Chunchi Liu, Yiqun Li, Changlin Bai, Chenzhou Hao, Maosheng Cheng, Dongmei Zhao*. Synthesis of novel β-propanamides to inhibit cholesteryl ester transfer protein (CETP). Chinese Chemical Letters, 28 (2017) 260-263.

5.     Chunchi Liu, Changqun Luo, Lijuan Hao, Qiong Wu, Honglei Xie, Shizhen Zhao, Chenzhou Hao, Dongmei Zhao*, Maosheng Cheng. Design, synthesis and biological evaluation of novel cholesteryl ester transfer protein inhibitors bearing a cycloalkane scaffold. European Journal of Medicinal Chemistry, 123 (2016), 410-419.

6.     Shizhen Zhao, Liyu Zhao, Xiangqian Zhang, Chunchi Liu, Chenzhou Hao, Honglei Xie, Bin Sun, Dongmei Zhao*, Maosheng Cheng. Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents. European Journal of Medicinal Chemistry, 123 (2016), 514-522.


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