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药物代谢实验室

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简历:


教育经历:

2017.09-2020.06  沈阳药科大学,药物分析,博士

2013.09-2016.06  沈阳药科大学,药物分析,硕士


工作经历:

2020.07-至今 中国科学院上海药物研究所烟台分所

2016.07-2017.08 北京新领先医药科技发展有限公司


研究方向:

从事新药临床前药代动力学研究,通过体外和动物体内的研究方法,揭示药物在体内的动态变化规律,获得药物的基本药代动力学参数,阐明药物的吸收、分布、代谢和排泄的过程和特征。


发表文章:

1、Rong Rong,  Xin Wang, Yuhan Dan, Ruizhen Zhang, Yunli Zhao, Zhiguo Yu. Determination of protein binding for novel 2-(2-hydroxypropanamido)-5-trifluoromethyl benzoic acid enantiomers to rats, dogs, and humans plasma by UPLC-MS/MS. Chirality, 2020, 32(5): 524-534. 

2、Rong Rong, Ruizhen Zhang, Xin Wang, Yuhan Dan, Yunli Zhao, Zhiguo Yu.  Synthesis, pharmacological evaluation and molecular docking of novel R-/S-2-(2-hydroxypropanamido)-5-trifluoromethyl benzoic acid as dual anti-inflammatory anti-platelet aggregation agents. Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 393: 967-978. 

3、Rong Rong, Qili Zhang, Ruizhen Zhang, Yuhan Dan, Xin Wang, Yunli Zhao, Zhiguo Yu. Exploring stereoselective excretion and metabolism studies of novel 2-(2-hydroxypropanamido)-5-trifluoromethyl benzoic acid enantiomers. RSC Advances, 2020,10: 27267-27279.

4、Rong Rong, Meiyu Cui, Qili Zhang, Meiyan Zhang, Zhiguo Yu and Yunli Zhao. Anesthetic constituents of Zanthoxylum bungeanum Maxim. pharmacokinetics studies. Journal of separation science, 2016, 39(14): P2728-2735.

5、Jiao Guan, Qili Zhang, Rong Rong, Fei Han, Heyun Zhu, Yunli Zhao, Aihua Song, Zhiguo Yu. Metabolic profile of 2-(2-hydroxypropanamido) benzoic acid in rats by ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Journal of Chromatography B, 2015, 993-994: 60-68.

6、Qili Zhang, Jiao Guan, Rong Rong, Yunli Zhao, Zhiguo Yu. Study on degradation kinetics of 2-(2-hydroxypropanamido) benzoic acid in aqueous solutions and identification of its major degradation product by UHPLC/TOF–MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 2015, 112: 1-7.


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